The post SODIUM AUROTHIOMALATE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>Disodium;gold(1+);2-sulfidobutanedioate;hydrate
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 408.09 g/mol |
2 | Physical appearance | Mixture of mono- and disodium salts; white to yellowish-white powder |
3 | Melting point | 100oC |
4 | Solubility | Very soluble in water and insoluble in alcohol |
5 | Octanol/water partition coefficient | N/A |
6 | Presence of ring | Not present |
7 | Number of chiral centers | Not present |
General SAR for Gold compounds can be summarized as follows:
i. Thiomalic acid is mixed with the aqueous suspension of gold(I)iodide.
ii. The resultant mono- and disodium salts are precipitated by the addition of ethanol.[2]
Gold sodium thiomalate is used for:
Side effects of Gold sodium thiomalate are:
Q.1 Which statements are correct with respect to the physicochemical properties of drug gold sodium thiomalate?
I. Molecular weight:408.09gm/mol
II. Appearance: Yellow white crystalline solid
III. Melting point: 153oC
a) I, II
b) II, III
c) I, II, III
d) I, III
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Gold sodium thiomalate | A. ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate |
ii. Diclofenac | B. (5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol |
iii. Diphenoxylate | C. Disodium;gold(1+);2-sulfidobutanedioate;hydrate |
iv. Codeine | D. [2-(2,6-Dichloroanilino)phenyl]acetic acid |
a) i-C, ii-D, iii-A, iv-B
b) i-D, ii-B, iii-A, iv-C
c) i-C, ii-A, iii-D, iv-B
d) i-B, ii-C, iii-D, iv-A
Q.3 Mechanism of action of Gold sodium thiomalate includes?
I. Inhibition of prostaglandin synthesis
II. Inhibition of acetylcholine synthesis
III. Suppressive effect on synovitis of active rheumatoid disease
IV. Alkylation of genetic material
a) II, IV
b) I, II, III
c) I, III
d) II, III, IV
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFFT
b) FTFT
c) FFTF
d) TTFF
Q.5 In the gold compound DMARDs, attachment of the gold with sulfur?
a) Decreases the activity
b) Increases the activity
c) Is essential for the activity
d) Has no impact on the activity of drug
Q.6 Type of ring present in the structure of Sodium aurothiomalate?
I. Oxazolidine
II. Naphthaline
III. Phenyl
IV. Furan
a) I, III
b) II, IV
c) I, III, IV
d) No ring structure present
Q.7 Side effect of drug Gold sodium thiomalate?
a) Seizures
b) Eye redness
c) Stomatitis
d) All of the above
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1-a
2-a
3-c
4-d
5-c
6-d
7-d
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