The post FLUFENAMIC ACID Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 281.23 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 133.5°C |
4 | Solubility | 9.09 mg/L |
5 | Octanol/water partition coefficient | 5.25 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | Not present |
General SAR for anthranylic acid derivatives can be summarized as follows:
Flufenamic acid can be synthesized by the reaction of 2-chlorobenzoic acid and 3-trifluoromethylaniline in the presence of potassium carbonate and copper fillings. [2]
Flufenamic acid is used for:
Side effects of Flufenamic acid are:
Q.1 Match the following with correct SAR of the class Anthranylic acid derivatives NSAIDs-
i. Substitution on anthranilic acid ring | A. Increases the activity |
ii. Meclofenamic acid is | B. Decreases the activity |
C. More active than Flufenamic acid | |
D. Less active than Flufenamic acid |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-C
d) i-B, ii-D
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFTF
b) FFFF
c) TTTT
d) TFFT
Q.3 Molecular weight of drug Flufenamic acid is?
a) 281.23 gm/mol
b) 458.6 gm/mol
c) 406.21 gm/mol
d) 162.1 gm/mol
Q.4 Flufenamic acid mechanism of action includes?
a) It Reduces inflammation
b) Synthesis of prostaglandins is reduced
c) COX is inhibited
d) All of the above
Q.5 Which amongst the following is a therapeutic use of drug Flufenamic acid?
a) Treatment of gout
b) Reducing pain
c) Bronchospasm
d) All of the above
Q.6 Which of the following drug and their classification are correct?
I. Neostigmine: ß-Adrenergic blocker
II. Flufenamic acid: Anthranylic acid NSAID
III. Enflurane: Phenothiazine antipsychotics
IV. Meperidine: Benzodiazepine sedative-hypnotic
a) III, IV
b) I, II, III
c) I, II, III, IV
d) II
Q.7 Flufenamic acid can be synthesized by the reaction of 3-(fluoromethyl)benzamine with?
a) 3-chlorobenzaldehyde
b) 2-chlorobenzoic acid
c) 2-chlorobutanoic acid
d) Oxalic acid
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1-c
2-d
3-a
4-d
5-b
6-d
7-b
The post FLUFENAMIC ACID Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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