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]]>In humans, the synthesis of nucleic acid is done by de-novo routes, that its through amphibolic intermediates.
Biosynthesis of purine nucleotides means synthesis of AMP and GMP.
In this method, synthesis of new product this done using amphibolic intermediates, that is the one which are already used in other reactions
In this process, the purine ring is formed from different structures like:
Using all these precursors, a ring structure is formed
Control in the synthesis of purine nucleotide is done by two factors:
1. Purine and pyrimidine are nutritionally classified as which type of components?
A. Essential
B. Non-essential
C. Semi-essential
D. None of the above
2. Synthesis of purine nucleotide can be done through how many process?
A. 2
B. 3
C. 4
D. 1
3. What are amphibolic intermediates?
A. Intermediates never used
B. These are one used only in certain physiologic condition
C. Intermediates already used
D. All of the above
4. C4 of purine nucleotide is derived from which precursor?
A. Glycine
B. Aspartate
C. Glutamine
D. None of the above
5. Which of the enzyme catalyzes the rate limiting step for the formation of IMP?
A. PRPP synthetase
B. GAR formyl transferase
C. IMP dehydrogenase
D. None of the above
6. Aspartate provides which of the following component of purine component?
A. N1
B. N7
C. N3
D. N9
7. Which of the following are included in purine nucleotide?
A. CMP, GMP
B. AMP, UMP
C. AMP, GMP
D. CMP, AMP
8. Match the following-
9. Addition of CO2 produces which compound in purine synthesis pathway?
A. AIR
B. CAIR
C. GAR
D. FGAR
10. Which of the following compound is a common intermediate in both De-novo pathway and salvage pathway?
A. PRPP
B. GAR
C. FGAM
D. none of the above
11. Succinyl group of SAICAR is liberated as which compound?
A. lactate
B. pyruvate
C. fumarate
D. both A and c
12. Which of the following statement is NOT true?
13. Which of the following enzymes regulate the de-novo synthesis of purine nucleotide?
A. PRPP synthetase
B. glutamine PRPP amido-transferase
C. IMP dehydrogenase
D. All of the above
14. Regulation of the de-novo synthesis of purine nucleotide depends on the concentration of which compound?
A. Ribulose-5-phosphate
B. PRPP
C. IMP
D. AIR
15. Ring structure of which of the compound forms IMP?
A. AICAR
B. FAICAR
C. both
D. none
ANSWERS:
1. Non-essential
2. 2
3. Intermediates already used
4. Glycine
5. None of the above
6. N1
7. AMP, GMP
8.
9. CAIR
10. PRPP
11. Fumarate
12
13. All of the above
14. PRPP
15. FAICAR
The post Biosynthesis of Purine Nucleotides: De-novo Pathway and MCQs GPAT, NEET, NET, UPSC and Pharmacist Exam appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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