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IUPAC nomenclature
2-[2-[bis(2-nitrooxyethyl)amino]ethyl-(2-nitrooxyethyl)amino]ethyl nitrate.
Classification
- Organic nitrate antianginal drug
Physiochemical Properties
| S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
| 1 | Molecular weight | 416.3 g/mol |
| 2 | Physical appearance | N/A |
| 3 | Melting point | N/A |
| 4 | Solubility | N/A |
| 5 | Octanol/water partition coefficient | N/A |
| 5 | Presence of ring | Not present |
| 6 | Number of chiral centers | Not present |
Mechanism of Action
i. Like other organic nitrate, Tenitramine releases NO.
ii. Activation of enzyme gunanylate cyclase
iii. Increase in concentration of cGMP within vascular smooth muscles
iv. Vasodilation occurs due to cGMP-dependent protein kinase.
Structure Activity Relationship
General structure activity of organic nitrate antianginal drugs can be summarized as:
- The number of nitrate groups determines the potency of organic nitrate for guanylate cyclase activation.
- Increase in nitric group increases the potency.
- Increase in lipophillicity doesn’t have major effect over activation of drug.
Method of synthesis
Nitration of (I) produces tenitramine.
Medicinal Uses
Tenitramine is a vasodilator
Side Effects
Side effects of Tenitramine are:
- Dizziness
- Headache
- Flushing
- Nausea
- Vomiting
- Weakness
- Restlessness
- Allergic reactions
MCQs
Q.1 Match the following with correct SAR of Organic nitrate antianginal drugs-
| i. Potency of drug can be increased by | A. Increasing the nitric group |
| ii. Number of nitrate groups determines | B. Decreasing the nitric group |
| C. Potency of drug | |
| D. Activation of adenylate cyclase enzyme |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-C
d) i-B, ii-D
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
- Tenitramine: 2-[2-[bis(2-nitrooxyethyl)amino]ethyl-(2-nitrooxyethyl)amino]ethyl nitrate
- Chlorothiazide: 6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide.
- Amlodipine: 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- Azatadine: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
a) FFTF
b) FFFF
c) TFFT
d) TTTT
Q.3 Molecular weight of drug Tenitramine is?
a) 416.3 gm/mol
b) 452.3 gm/mol
c) 248.5 gm/mol
d) 978.1 gm/mol
Q.4 Mechanism of action of Tenitramine includes?
a) Inhibition of sodium-potassium-chloride cotransportors
b) Release of NO
c) Inhibition of hydrogen-potassium pump
d) All of the above
Q.5 Which amongst the following is a therapeutic use of drug Tenitramine?
a) As an anticonvulsant
b) As a vasodilator
c) As an antipsychotic
d) As an anesthetic
Q.6 Which of the following drug and their classification are correct?
I. Tenitramine: Antianginal drug
II. Furosemide: Diuretics
III. Disopyramide: Anti-arrhythmic drug
IV. Verapamil: Calcium channel blocker
a) I ,II, IV
b) II, IV
c) I, II, III, IV
d) I, III
Q.7 Type of ring present in the structure of Tenitramine?
a) No ring present
b) Pyridine
c) Pyrimidine
d) Pyridine
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ANSWERS
1-a
2-d
3-a
4-b
5-b
6-c
7-a
The post TENITRAMINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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