The post THIORIDAZINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride
Thioridazine hydrochloride is phenothiazine antipsychotic drug.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 407 g/mol |
2 | Physical appearance | Pale yellow solid |
3 | Melting point | 158-160°C |
4 | Solubility | Soluble in water |
5 | Octanol/water partition coefficient | N/a |
6 | Presence of ring | Phenothiazine, piperidine |
7 | Number of chiral centers | 1 |
Structure activity relationship of phenothiazine can be described as follows:
Thioridazine can be synthesized through reaction of 2-(methylthio)-10H-phenothiazine with 2-(2-chloroethyl)-N-methylpiperidine in refluxing xylene in the presence of refluxing sodium amide.
Thioridazine hydrochloride is used for:
Side effects of Thioridazine hydrochloride are:
Q.1 What are the correct statements related with the physicochemical properties of thioridazine hydrochloride drug?
I. Molecular weight = 407 gm/mol
II. It appears as pale yellow solid
III. It is soluble in water
IV. Phenothiazine ring is present in the structure
a) I, II, III
b) I, II, IV
c)III, IV
d) I. II. III. IV
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Thioridazine | A. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine |
ii. Mephobarbital | B. 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione |
iii. Triflupromazine | C. Phenyl-5-ethyl-1-methylbarbituric acid |
iv. Thiopental | D. N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine |
a) i-B, ii-C, iii-A, iv-D
b) i-C, ii-A, iii-D, iv-B
c) i-A, ii-C, iii-D, iv-B
d) i-D, ii-A, iii-C, iv-B
Q.3 Types of receptors blocked by the Thioridazine hydrochloride drug?
I. Dopaminergic D1
II. Dopaminergic D2
III. ß-adrenoceptors
IV. α-adrenoceptors
a) I, III, IV
b) I, II
c) III, IV
d) I, II, IV
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFTF
b) TTFF
c) FFTT
d) FFFT
Q.5 Greater potency of phenothiazines with trifluoromethyl substitution is due to?
a) Greater number of favourable Van der Waal’s contacts
b) Bleaching action of chlorine
c) Affinity of fluorine with potassium is higher
d) High molecular weight of fluorine
Q.6 Starting chemicals requires for the synthesis of thioridazine drug are?
I. 2-(methylthio)-10H-phenothiazine
II. 2-(2-chloroethyl)-N-methylpiperidine
III. Sodium amide
IV. 4-chloro-3-cyclopentene
a) I, III, IV
b) I, II, III
c) II, III, IV
d) I, II, IV
Q.7 Side effect of drug Thioridazine hydrochloride are?
a) Tremors
b) Infections
c) Difficulty in urination
d) All of the above
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1-d
2-c
3-d
4-b
5-a
6-b
7-d
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