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]]>7-[(hydroxidi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Tiotropium is a long-acting, antimuscarinic bronchodilator.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 392.5 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 218-220°C. |
4 | Solubility | Feely soluble in dimethyl sulfoxide; sparingly soluble in water. |
5 | Presence of ring | Present |
6 | Number of chiral centers | 5 |
i. Scopine reacts with compoud with formula (1) to give scopine ester.
ii. Scopine ester undergoes oxidation to give Tiotropium.
Tiotropium is used for:
Side Effects
Side effects of Tiotropium are:
Q.1 Tiotropium?
a) Stimulate nicotinic receptors
b) Stimulates muscarinic receptors
c) Inhibits nicotinic receptors
d) Inhibits muscarinic receptors
Q.2 Therapeutic use of drug tiotropium is/are?
a) Asthma
b) Bronchitis
c) Emphysema
d) All of the above
Q.3 Which amongst the following are the correct statements with respect to the SAR of drug Tiotropium?
I. Either R1 or R2 must be heterocyclic or carbocyclic.
II. The R3 group can be hydrogen, hydroxyl, hydroxymethyl or amide.
III. Most potent derivatives has X as an ester.
a) II
b) I
c) II, I
d) I, II, III
Q.4 The starting chemicals required for the synthesis of drug Tiotropium?
a) 2-(2’,2’-dimethoxyethyl)propane-1,3-diol.
b) Epoxypropane
c) Cyclobutane
d) Scopine
Q.5 Correct sequence for the True/False for the physiochemical properties of the drug Tiotropium?
a) TTT
b) TTF
c) FFT
d)FTF
Q.6 Correct statements for the IUPAC nomenclatures of the are?
I. Pilocarpine: (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one.
II. Orphinendrine: N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid.
III. Tiotropium: 7-[(hydroxidi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
IV. Carbachol: 2-[(Aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride.
a) I, III
b) II, IV
c) I, II, III, IV
d) I, II, IV
Q.7 Match the following drugs with their correct classifications-
i. Pilocarpine | A. Acetylcholinestrase inhibitor |
ii. Physostigmine | B. Acetylcholine antagonist-muscarinic antagonist |
iii. Tiotropium | C. Acetylcholine mimetic-muscarinic agonist |
iv. Metocurine | D. Nicotinic antagonist |
a) i-C, ii-A, iii-B, iv-D
b) i-B, ii-D, iii-A, iv-C
c) i-A, ii-B, iii-D, iv-C
d) i-B, ii-C, iii-D, iv-A
1-d
2-d
3-d
4-d
5-d
6-c
7-a
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