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]]>2-Benzyl-4,5-dihydro-1H-imidazole.
Tolazoline is nonselective α-adrenergic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 160.22 g/mol |
2 | Physical appearance | Present in solid form |
3 | Melting point | 174°C |
4 | Solubility | 373 mg/L |
5 | Octanol/water partition coefficient | 2.65 |
6 | Presence of ring | Benzene and imidazole |
7 | Number of chiral centers | Not present |
Heterecyclation of the ethyl ester of iminophezylacetic acid with the help of ethylenediamine give tolazoline.
Tolazoline is used for the treatment of:
Side effects of Tolazoline are:
MCQs
Q.1 “2-Benzyl-4,5-dihydro-1H-imidazole” is the IUPAC nomenclature of which drug?
a) Metaraminol
b) Tolazoline
c) Prazosin
d) Dihydroergotamine
Q.2 Type of ring structure present in Tolazoline?
a) Imidazole ring
b) Benzene ring
c) Ergoline ring
d) Both a) and b)
Q.3 Match the following with correct classifications of the drugs.
i. Tolazoline | A. ß1-adrenergic agonist |
ii. Naphazoline | B. α1-adrenergic agonist |
iii. Dobutamine | C. α-adrenergic antagonist |
iv. Phenoxybenzamine | D. Nonselective α-agonist |
a) i-C, ii-B, iii-A, iv-D
b) i-D, ii-C, iii-B, iv-A
c) i-A, ii-D, iii-C, iv-B
d) i-B, ii-A, iii-D, iv-C
Q.4 Correct steps for the mechanism of action of the drug…..
I. Effect on peripheral smooth muscles.
II. Reduction in pulmonary and aterial blood pressure
III. Vasodilation
a) II – I – III
b) III – II – I
c) III – I – II
d) I – III – II
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug…..
a) FTT
b)TFT
c)FFT
d) TTT
Q.6 Tolazoline can be produced through heterocyclation of ethyl ester of?
a) Paraaminophenol
b) Hydroxyphenyl acetone
c) Ethylenediamine
d) Iminophezylacetic acid
Q.7 The drug Tolazoline is mainly used for?
a) Treatment of hypotension
b) During fall in level of chlorine in blood
c) Decreasing pulmonary vascular resistance
d) Treatment of intestinal bleeding
1-b
2-d
3-a
4-d
5-a
6-d
7-c
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