The post TOREMIFENE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>2-[4-[(1Z)-4-Chloro-1,2-diphenyl-but-1-en-1-yl]phenoxy]-N,N-dimethylethanamine.
Toremifene is a selective estrogen receptor modulator. [1]
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 406 g/mol |
2 | Appearance | Present in the solid form |
3 | Melting point | 108-110°C |
4 | Solubility | 0.000409 mg/ ml in water |
5 | Octanol/water partition coefficient | 6.8 |
6 | Presence of ring | Aryl rings |
7 | Number of chiral centers | No chiral centers present. |
i. 1,2-diphenylethanone is reacted with EtONa and 1-((2-bromoethoxy)methyl)benzene to give 4-(benzyloxy)-1,2-diphenylbutan-1-one.
ii. The latter compound is then reacted with THPOC6H4MgBr, and thereafter it is reduced.
iii. In the next step, the formed compound is reacted with 2-chloro-N,N-dimethylethanamine.
iv. Treatment with HCl gives toremifene.
The drug used for the treatment of metastatic breast cancer in the female patients who are postmenopausal and the tumors are estrogen receptor positive.
Q.1 Which term is associated with the drug Toremifene?
a) Fareston
b) Shantinib
c) Oncocarbin
d) Honvan
Q.2 Match the following with respect to the approximate molecular weights of drugs
i. Toremifene | A. 296 gm/mol |
ii. Ethinylestradiol | B. 406gm /mol |
iii. Tamoxifen | C. 360 gm/mol |
iv. Prednisolone | D. 371.5 gm/mol |
a) i-B, ii-A, iii-C, iv-D
b) i-A, ii-B, iii-D, iv-C
c) i-A, ii-B, iii-C, iv-D
d) i-B, ii-A, iii-D, iv-C
Q.3 The drug Toremifene shows its action through
a) Binds with estrogen receptors and shows estrogenic properties
b) Binds with estrogen receptors and shows antiestrogenic properties
c) Binds with estrogen receptor and shows either estrogenic, antiestrogenic or both the properties.
d) None of the above
Q.4 The correct order for the synthesis of the drug Toremifene is?
I. Reaction with 2-chloro-N,N-dimethylethanamine
II. Reaction with THPOC6H4MgBr and reduction.
III. 1,2-diphenylethanone is reacted with EtONa and 1-((2-bromoethoxy)methyl)
IV. Reaction with HCl.
a) II – III – I – IV
b) IV – III – I – II
c) I – II – IV – III
d) III – II – I – IV
Q.5 Predict the incorrect statements from the following with respect to the classification of the drugs-
I. Prednisolone is a glucocorticoid.
II. Fosfestrol is a selective estrogen down regulator.
III. Torenifene is a selective estrogen modulator.
IV. Nafarelin is a GnRH analogue.
a) II & IV
b) II
c) III & IV
d) I & II
Q.6 The correct sequence of True and False for the given statements with respect to the side effects of drug Tornifene is?
I. Vaginal discharge is a common side effect.
II. Depression is a less common side effect.
III. Increase in appetite may occur in patients taking the drug.
IV. Insomia is a less common side effect.
a) TFTF
b) TTFT
c) FFTF
d) FTFT
Q.7 Which amongst the following drugs has the highest melting point?
a) Toremifene
b) Prednisolone
c) Tamoxifen
d) Ethinylestradiol
1-a
2-d
3-c
4-d
5-b
6-b
7-b
The post TOREMIFENE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>