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]]>10-[3-(4-methylpiperazin-1-yl)propyl]- 2-(trifluoromethyl)-10H-phenothiazine.
Trifluoperazine is phenothiazine antipsychotic drug.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 407.5 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 232°C |
4 | Solubility | Freely soluble in water |
5 | Octanol/water partition coefficient | 5.03 |
6 | Presence of ring | Phenothiazine, piperazine |
7 | Number of chiral centers | Not present |
Structure activity relationship of phenothiazine can be described as follows:
Trifluoperazine can be synthesized by reacting 2-(trifluoromethyl)-10H-phenothiazine with 1-(3-chloropropyl)-4-methylpiperazine in the presence of sodium amide.
Trifluoperazine is used for:
Side effects of trifluoperazine are:
Q.1 “10-[3-(4-methylpiperazin-1-yl)propyl]- 2-(trifluoromethyl)-10H-phenothiazine” is the IUPAC nomenclature of which drug?
a) Trifluoperazine
b) Promazine
c) Fluoxetine
d) Quetiapine
Q.2 The approximate molecular weight of the drug Trifluoperazine is?
a) 152.6 gm/mol
b) 407.5 gm/mol
c) 578.6 gm/mol
d) 446 gm/mol
Q.3 Match the following with correct classifications of the drugs.
i. 2,5-dimethoxy-4-iodoamphetamine | A. 5-HT receptor antagonist |
ii. Granisetron | B. Hallucinogenic agent |
iii. Almotriptan | C. 5-HT receptor agonist |
iv. Trifluoperazine | D. Phenothiazine |
a) i-B, ii-A, iii-C, iv-D
b) i-D, ii-A, iii-B, iv-C
c) i-A, ii-B, iii-D, iv-C
d) i-D, ii-B, iii-A, iv-C
Q.4 Choose the correct statements related with the Mechanism of action of drug trifluoperazine?
I. Blocks Dopamine D1 receptors
II. Blocks Dopamine D2 receptos
III. Stimulates α-adrenoceptors
IV. Stimulates ß-adrenoceptor
a) I, II
b) III, IV
c) I, II, III
d) II, III, IV
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug trifluoperazine?
a) TFTT
b) TTFF
c) FFTT
d) FFTF
Q.6 Trifluoperazine can be synthesized by the interaction of?
a) Phenothiazine derivative and alkylamide
b) Piperazine derivative and Sulfuric acid
c) Phenothiazine derivative and Piperazine derivative
d) None of the above
Q.7 The drug Trifluoperazine is mainly used for?
a) Treatment of Psychotic disorders
b) Treatment of Schizophrenia
c) Reducing aggressiveness
d) All of the above
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1-a
2-b
3-a
4-a
5-b
6-c
7-d
The post TRIFLUOPERAZINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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