The post TRIHEXYPHENIDYLE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(RS)-1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol.
Trihexyphenidyl is an acetylcholine antagonist. It is a muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 301.5 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 258.5°C. |
4 | Solubility | 18 mg/L in water |
5 | Octanol/water partition coefficient | 4.49 |
6 | Presence of ring | Piperidine, benzene, cyclohexyl |
7 | Number of chiral centers | 1 |
i. Acetophenone and piperidine undergoes Mannich condensation in presence of formaldehydeto produce 3-piperidinopropiophenone.
ii. The latter compound undergoes Gringnard’s reaction with cyclohexylmagnesium chloride to give trihexyphenidyl.
Trihexyphenidyl is used for:
Side effects of Trihexyphenidyl are:
Q.1 “RS)-1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol” is the IUPAC nomenclature of which drug?
a) Trihexyphenidyl
b) Propantheline
c) Oxybutynin
d) Oxazepam
Q.2 Melting point of Trihexyphenidyle is?
a) 152-162°C
b) 129-130°C
c) 205.5°C
d) 258.5°C
Q.3 Match the following with correct classifications of the drugs.
i. Trihexyphenidyle | A. Benzodiazepine sedative-hypnotic |
ii. Oxazepam | B. Barbiturate |
iii. Clozapine | C. Muscarinic antagonist |
iv. Thiamylal | D. Benzpines |
a) i-A, ii-C, iii-D, iv-B
b) i-C, ii-A, iii-D, iv-B
c) i-A, ii-B, iii-D, iv-C
d) i-C, ii-B, iii-A, iv-D
Q.4 Mechanism of action of Trihxyphenidyl is based on?
a) Blocking the Muscarinic acetylcholine receptors
b) Blocking the nicotinic acetylcholine receptors
c) Increasing the bioavailability of dopamine
d) Both a) and c)
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug trihexyphenidyl
a) TFTF
b) FTFT
c) TTTT
d)FFTF
Q.6 Steps involved in the synthesis of trihexyphenidyl from acetophenone in the correct sequence is?
I. Mannich condensation with piperidine
II. Grignard’s reaction with cyclohexylmagnesium chloride
III. Reaction with hydrazine
a) I – II – III
b) I – III
c) I – II
d) II – I – III
Q.7 The drug trihexyphenidyl is mainly used for?
a) Parkinson’s disease
b) Hypertension
c) Depression
d) Constipation
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1-a
2-d
3-b
4-d
5-c
6-c
7-a
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