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10-(3-dimethylamino-2-methylpropylphenothiazine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 298.4 g/mol |
2 | Physical appearance | Crystals |
3 | Melting point | 68oC |
4 | Solubility | 0.942 mg/ml |
5 | Octanol/water partition coefficient | 4.6 |
5 | Presence of ring | Phenothiazine |
6 | Number of chiral centers | 1 |
Structure activity of phenothiazine derivatives antihistamines can be summarized as:
General structure activity of first generation H1-receptors antagonist can be summarized as:
Alkylation of phenothiazine with 1-dimethylamino-2-methyl-propylchloride gives trimeprazine. [1]
Trimeprazine is used for treatment of:
Side effects of Trimeprazine are:
Q.1 What can be the correct IUPAC nomenclature of Trimeprazine?
a) 2-(diphenylmethoxy)-N,N-dimethylethanamine
b) 10-(3-dimethylamino-2-methylpropylphenothiazine
c) (RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
d) (R)-(+)-2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-imidazole
Q.2 Which amongst the following statements is/are incorrect related to the Phenothiazine derivative antihistamine drugs?
I. There are 2-3branched alkyl chain between the ring system and the nitrogen atom.
II. On unbranching, antipsychotic series of drugs can be obtained.
a) I
b) I, II
c) II
d) None
Q.3 Types of rings present in the structure of Trimeprazine?
I. Imidazole
II. Pyridine
III. Phenothiazine
IV. Phenyl
a) I, II
b) I, IV
c) II, IV
d) III
Q.4 Side effects of drug Trimeprazine is/are?
a) Allergic reactions
b) Trouble swallowing
c) Upset stomach
d) All of the above
Q.5 Match the following drugs with their correct molecular weight-
i. Trimeprazine | A. 166.24 gm/mol |
ii. Pyrrobutamine | B.240.34 gm/mol |
iii. Edrophonium | C. 298.4 gm/mol |
iv. Pheniramine | D. 311.8 gm/mol |
a) i-A, ii-B, iii-C, iv-D
b) i-C, ii-A, iii-B, iv-D
c) i-C, ii-D, iii-A, iv-B
d) i-A, ii-C, iii-D, iv-B
Q.6 An example of drug from class phenothiazine derivative antihistamine drug?
a) Trimeprizine
b) Besoprolol
c) Hydroxyamphetamine
d) Ephedrin
Q.7 Octanol/water partition coefficient of Trimeprazine is?
a) 7.3
b) 5.3
c) 4.6
d) 1.6
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1-b
2-d
3-d
4-d
5-c
6-a
7-c
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