The post UMIFENOVIR Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses in Influenza appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>Ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-meth yl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate.
Classification
Umifenovir belongs to class fusion inhibitors.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 477.74 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 133-137°C |
4 | Solubility | Water solubility is 0.00678 mg/ml |
5 | Presence of ring | Indole, benzene |
6 | Number of chiral centers | Not present |
The drug acts on aromatic residues within the glycoprotein which are important for cellular recognition and fusion. This interfere with clathrin-mediated exocytosis and intracellular trafficking, directly at the plasma membrane itself. This stabilizes the plasma membrane and prevent the entry of virus. [1]
Formaldehyde, dimethylamine and ethyl-6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate to get Umifenovir.
Umifenovir is used for:
Side effects of Umifenovir are:
Q.1 Choose the correct statements related to the physicochemical properties of drug umifenovir-
I. Molecular weight is 477.74 gm/mol
II. Present in solid form
III. It is very soluble in water
IV. Melting point is 273K
a) I, II
b) I, III
c) III, IV
d) I, III, IV
Q.2 Match the following of the drugs with their correct Trade names.
i. Umifenovir | A. Topotel |
ii. Daunorubicin | B. Arbidol |
iii. Topotecan | C. Dacmozen |
iv. Dactinomycin | D. Myeleran |
a) i-B, ii-C, iii-D, iv-A
b) i-B, ii-C, iii-A, iv-D
c) i-C, ii-A, iii-D, iv-B
d) i-A, ii-D, iii-B, iv-C
Q.3 Umifenovir do not let the virus to?
a) Use the host machinery
b) Infect other cells
c) Grow in size
d) Synthesize DNA
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TTTT
b) TTTF
c) FTTT
d) TFTT
Q.5 When the dimethylamino group at indole position-4 arbidol is removed?
a) Biding affinity increases
b) Activity of drug increases
c) Biovailability increases
d) Activity decreases
Q.6 Type/s of ring present in the structure of Umifenovir?
I. Cyclopentyle
II. Indole
III. Benzene
a) II, III
b) I, II
c) I
d) I, II, III
Q.7 Side effect of drug Umifenovir?
a) Allergic reactions
b) Hallucinations
c) Confusion
d) All of the above
Participate in Online FREE GPAT TEST: CLICK HERE
Participate in Online FREE Pharmacist TEST: CLICK HERE
Participate in Online FREE Drug Inspector TEST: CLICK HERE
1-a
2-b
3-b
4-d
5-a
6-a
7-a
The post UMIFENOVIR Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses in Influenza appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>