Anti Cancer Drug Mechanism Part 1-Alkylating Agents & Antimetabolite

Alkylating agents are reactive to DNA and cellular proteins and the primary mode of action is mostly through cross-linking of DNA strands, inhibiting replication of DNA and transcription of RNA. Some antimetabolites are structural analogs of normal molecular essentials for cell growth. After intaking into cells the analogues change to substances to interfere with DNA or RNA synthesis.

MCQ on Anti Cancer Drug Mechanism

Q. 1 What is the mechanism of Action of 5 Flurouracil

A. It block thymidine synthetase

B. It block Helicase

C. It block Topoisomerase

D. It block DNA Polymerase

Q. 2 What is the mechanism of Action of Methotrexate

A. It block thymidine synthetase

B. It block DHFR

C. It block Topoisomerase

D. It block DNA Polymerase

Q. 3 By which bond Alkylating agents bind to nitrogen bases

A. Hydrogen Bond

B. Covalent Bond

C. Ionic Bond

D. All

Q. 4 What is the mechanism of Action of 6 Mercaptopurine

A. It block thymidine synthetase

B. It block DHFR

C. It block Purine synthesis

D. It block DNA Polymerase

Q. 5 Nitrogen Mustard act on

A. Cell Cycle

B. Purine Synthesis inhibition

C. Pyrimidine Base synthesis inhibition

D. NONE

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