Comparison Chart of Cephalosporin Generations, MCQ for GPAT & NEET PG

Comparison chart of Cephalosporin Generations

Generation	Spectrum of Activity	Gram-Positive Coverage	Gram-Negative Coverage	Resistant to β-lactamase?	Key Examples	Clinical Uses
1st	Narrow	Good	Limited	No	Cefazolin, Cephalexin	Skin infections, surgical prophylaxis, UTIs
2nd	Intermediate	Moderate	Better than 1st	Slightly	Cefuroxime, Cefoxitin	Respiratory tract infections, abdominal infections
3rd	Broad	Less than 1st/2nd	Excellent	Yes	Ceftriaxone, Ceftazidime	Meningitis, gonorrhea, sepsis
4th	Broadest	Good	Excellent + Pseudomonas	Yes	Cefepime	Hospital-acquired infections, febrile neutropenia
5th	Broad (Advanced)	Best (incl. MRSA)	Good	Yes	Ceftaroline	MRSA infections, CAP, SSTIs

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Multiple Choice Questions (MCQs)

1. Which generation of cephalosporins is most effective against MRSA?
   A. 1st
   B. 3rd
   C. 5th
   D. 2nd
   Answer: C. 5th

2. Which of the following is a 4th generation cephalosporin?
   A. Cephalexin
   B. Cefepime
   C. Ceftaroline
   D. Cefuroxime
   Answer: B. Cefepime

3. Which cephalosporin generation has the best Gram-negative coverage, including Pseudomonas?
   A. 1st
   B. 2nd
   C. 4th
   D. 5th
   Answer: C. 4th

4. Ceftriaxone is primarily used in the treatment of which condition?
   A. Skin infections
   B. Pneumonia caused by MRSA
   C. Gonorrhea
   D. Otitis externa
   Answer: C. Gonorrhea

5. Which of the following cephalosporins is most suitable for surgical prophylaxis?
   A. Ceftazidime
   B. Cefazolin
   C. Cefuroxime
   D. Ceftaroline
   Answer: B. Cefazolin

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