GPAT 2016 TO GPAT 2020 PHARMACEUTICAL ANALYSIS Questions and Answer

GPAT 2016 MCQ OF PHARMACEUTICAL ANALYSIS

1.The correct order for the basic features of a mass spectrometer is

(a) Acceleration, deflection, detection, ionization

(b) Ionization ,Acceleration, deflection, detection

(c) Acceleration, ionization, deflection, detection

(d) Acceleration, deflection, ionization, detection

2. In NMR spectrum, a signal is observed as triplet. What will be the ratio of relative peak areas in this signal

(a) 1:1:1 (b) 1:2:1 (c) 1:3:1 (d) 1:4:1

3.Carabilide shows stongs IR absorption in which of the following range in CM¯¹

(a) 3200-3600 (b) 1640-1690 (c) 1000-1300 (d) 2210-2260

4.Which one of the following technique is used to determine glass transition temperature

(a) X-ray diffractometry

(b) Raman spectroscopy

(c) Differential scanning calorimetry

(d) Atomic forced microscopy

5.. In polarography………………current must be blocked

(a) Residual (b) Migration (c) Diffusion (d) None

ANSWER KEY OF GPAT 2016

1. B

2. B

3.B

4.C

5.D

GPAT 2017 Old Question

1. One of the principle upon which HPLC detector functions is

(a) Redox property of solute is the basis for functioning of Electrochemical detectors

(b) Fluorimetric detector has high selectivity and low sensitivity
(c) Small difference in Refractive Index of mobile phase permit precise measurements in Refractive index detectors

(d) UV detector function based on its ability to detector

2.Which of the following techniques is not useful to detect polymorphs

(a) DSC (b) HPLC (c) PXRD (d) Melting point determination

3. Which among the following rules about spin – spin coupling and bond multiplicities are correct with regard to NMR spectra

(a) Coupling constant rarely exceeds 20 cps whilechemical shifts are over 1000 cps

(b) Spin – Spin interactions are dependent of strength of the applied field

(c) Coupling constant is increase with distance

(d) Equivalent nuclei interact with each other to show interaction

4.Which among the following statements related to Ceric sulphate as oxidizing agent, as titrant are correct

(a) Ce (IV) during reaction exists as an anionic complex in media of sulphuric acid

(b) Ionic equation is ce³→ce² + e¯

(c) Formal potential of Ce(III) Ce (II) couple is 1

(d) Ce (IV) does not permit use of HCl as reducing media

5. If the excitation energy of the resonance level is 2.10 eV (when hc=12,330) then the wave-lengthof resonance line of sodium atoms is ________

(a) 577.2 nm (b) 587.2 nm (c) 567.2 nm (d) 597.2 nm

6. Which of the following techniques is not useful to detect polymorphs

(a) DSC (b) HPLC (c) PXRD (d) Melting point determination

ANSWER KEY OF 2017

1.A

2. B

3.A

4.A

5.B

6.B

GPAT 2018

1.What quantity of an indicator solution shall be added when quantity is not mentioned in an assay or test?

(a) 0.1 ml (b) 0.05 ml (c) 0.2 ml (d) 0.5 ml

2. In Kjeldahl method, sample containing nitrogen is digested with ______.

(a) Concentrated sodium hydroxide (b) Fuming nitric acid

(c) Concentrated sulphuric acid (d) Strong ammonia solution

3. What is the concentration of paracetamol in a 0.1 N sodium hydroxide solution, whose absorption in a 1 cm cell at its λmax, 257 nm, was found to be 0.825? The A (1%, 1 cm) in the IP monograph of paracetamol is given as 715 at 257 nm

(a) 1.1 g/100 ml (b) 0.0011 mg/100 ml (c) 0.0011 g/100 ml (d) 0.0011 g/100 ml

4. The unit for specific absorbance A (1%, 1cm) is:

(a) μg/mL (b) mg/L (c) liter mole-1 cm-1 (d) dl g-1 cm-1

5. What is the nuclear magnetic resonance frequency of 1H in a 7.05 Tesla magnetic field strength? (a) 300.0 MHz (b) 200.0 MHz (c) 60.0 MHz (d) 100 MHz

6. What is Hydrogen Deficiency Index (HDI) value for toluene?

(a) 1 (b) 2 (c) 3 (d) 4

7.. In NMR, the aromatic proton resonate in a characteristic narrow range at:

(a) δ6.5 – δ 8.0 (b) δ 11.0 – δ 12.0 (c) δ 2.0 – δ 4.0 (d) δ 0.7 – δ 1.3

ANSWER KEY OF GPAT 2018

1.A

2.C

3.C

4.D

5.A

6.D

7.A

GPAT 2019 

1 Choose the correct sequence of process during Atomization in atomic absorption spectroscopy?

(a) Desolvation → Nebulization→ Dissociation →Volatilization → Ionization ion

(b) Nebulization → Desolvation → Volatilization →Dissociation → Ionization ion

(c) Desolvation → Nebulization → Volatilization → Dissociation →Ionization ion

(d) Nebulization →Volatilization → Desolvation →Dissociation →Ionization

2. Which among the following carrier gases has the highest thermal conductivity ?

(a) Nitrogen (b) Oxygen (c) Helium (d) Compressed Air

3. PM indicators are used in :

(a) Redox titrations (b) Non-Aquous titrations (c) Acid-base titrations (d) Complexometric titrations

4.When 50 ml of sodium hydroxide (0.1 M) is added to 100 mL of 0.1 M acetic acid, pH of the resultant solution is …………… 5Ka of acetic acid 1.82 10 ¯5

(a) 8.58 (b) 7.42 (c) 4.74 (d) 7.06

ANSWER KEY OF 2019

1.B

2.C

3.D

4.D

 

GPAT 2020 Paper Questions Asked from Pharmaceutical Analysis

1.The principle of gas –  liquid chromatography is  

a.Ion exchange chromatography

b. Adsorption chromatography

c. Affinity chromatography

d.Partition chromatography

2.What is the approximate chemical shift ranges for protons attached to aldehydic groups ?

a. 4-8 δ

b. 9.5-10.0 δ

c. 1.5-3.5 δ

d. 6-7.9 δ

3.The solvent used in NMR SPECTROSCOPY with the highest level of deuteriation among these is :

a. Deuterum oxide

b.Deuterichloroform

c.Deuteriomethanol

d.Deuterioacetone

4.Globar source in infra red spectrophotometer is 

a. Nichrome wire

b. Tungsten filament

c.Rhodium wire heated in ceramic

d.Silicon carbide rod

ANSWER KEY 

1.D

2.B

3.B

4.D

 

 

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