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Category: GPAT Preparation

5-FLOUROURACIL (5-FU) Synthesis, SAR, MCQ,Structure,Therapeutic Uses, Chemical Property

5-Fluorouracil (5-FU)   IUPAC nomenclature 5-Fluoro-1H,3H-pyrimidine-2,4-dione Classification 5-Fluorouracil falls under the category of pyrimidine antagonist antimetabolite. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 130.08 g/mol 2 Appearance White crystalline powder 3 Melting point 283 °C 4 […]

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CYTARABINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Cytarabine  IUPAC nomenclature 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5- (hydroxymethyl)oxolan-2-yl] pyrimidin-2-one Classification Cytarabine falls under the category of pyrimidine antagonist antimetabolite. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 243.22 g/mol 2 Appearance Colorless crystalline powder 3 Melting point 212.5 °C 4 […]

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Vasaca: Biological Source, Medicinal Uses, Chemical Constituents, Adulterants and MCQ

VASACA 1. Biological sources : • Also known as Adhatoda vasica or Malabar nut. • It belongs to the Acanthaceae family. • The biological source of vasaca is dried and fresh leaves of this plant. 2. Morphological features : • […]

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Kurchi: Biological Source, Chemical constituents, Uses, Adultrants, Morphology and MCQ

KURCHI 1. Biological sources: • Kurchi belongs to the Apocynaceae family. • Kurchi bark consist of dried stem bark of Halarrhena antidysenterica(H.pubescens). • It also known as Halorrhenna. • The bark of kurchi is collected from the tree by making […]

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AZATHIOPRINE Synthesis, SAR, MCQ,Structure and Therapeutic Uses

Azathioprine  IUPAC nomenclature 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine     Classification Azathioprine falls under the category of purine antagonist antimetabolite. It is also an immunosuppressive agent. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 277.27 g/mol 2 Appearance Pale yellow crystalline […]

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FLUDARABINE Synthesis, SAR, MCQ,Structure and Therapeutic Uses

Fludarabine   IUPAC nomenclature [(2R,3S,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)- 3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid Classification Fludarabine falls under the category of purine antagonist antimetabolite. It is also an immunosuppressive agent. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 285.23 g/mol 2 Appearance They are […]

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METHOTREXATE SAR, Synthesis, Mechanism of action, Therapeutic actions, Side effects and MCQ

Methotrexate IUPAC nomenclature (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid   Classification Methotrexate falls under the category of Folate antagonist antimetabolite Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 454.4 g/mol 2 Appearance Yellow to brown crystalline powder 3 Melting point 195°C […]

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6-MERCAPTOPURINE SAR, synthesis, mechanism of action, therapeutic actions, side effects and mcq

6-Mercaptopurine (6-MP)  IUPAC nomenclature 3,7-dihydropurine-6-thione   Classification 6-Mercaptopurine falls under the category of purine antagonist antimetabolite. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 152.18g/mol 2 Appearance Yellow to dark yellow crystalline powder 3 Melting point 313 […]

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6-THIOGUANINE Synthesis, SAR, MCQ,Chemical Structure and Therapeutic Uses

6-Thioguanine (6-TG)    IUPAC nomenclature 2-amino-1H-purine-6(7H)-thione   Classification 6-Thioguanine falls under the category of purine antagonist antimetabolite. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 167.19g/mol 2 Appearance Yellow crystalline powder 3 Melting point More than 360 […]

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