Notes: Anti-Cancer Drug Mechanisms of Alkylating and Antimetabolite Agents
1. Alkylating Agents Mechanism of Action: Alkylating agents add alkyl groups (e.g., methyl, ethyl) to DNA, primarily at the N7 position of guanine. This causes: DNA cross-linking (intra- and inter-strand). Mispairing of bases. DNA strand breakage. Inhibition of DNA replication […]