Typhoid Fever: Causative agent, Symptom, Pathogenesis,Diagnostic Test & Treatment MCQ

Typhoid Fever: Causative agent, Symptom, Pathogenesis,Diagnostic Test & Treatment MCQ

Typhoid Fever: Causative agent, Symptom, Pathogenesis,Diagnostic Test & Treatment MCQ

A.] CAUSATIVE AGENT: SALMONELLA TYPHI (CAUSE TYPHOID FEVER)

SALMONELLA PARATYPHI (CAUSES PARATYPHOID FEVER)

B.] STRUCTURE OF SALMONELLA: FLAGELLATED, ROD SHAPED AND GRAM NEGATIVE BACTERIA.

C.] PATHOGENESIS: 

a.) THE TYPHOID BACILLI ARE INGESTED THROUGH EITHER CONTAMINATED FOOD AND WATER OR BY CONSUMING COMMERCIALLY RAISED CHICKEN’S MEAT.

b.) INCUBATION PERIOD FOR BACTERIA IS FOR ABOUT THREE DAYS TO THREE MONTHS AND DURING THIS PERIOD THE BACILLI INVADE LYMPHOID TISSUE AND PEYER’S PATCHES OF SMALL INTESTINE AND PROLIFERATE  i.e; THEY MULTIPLY.

c.) HUMANS ARE THE ONLY ONE HOST OF SALMONELLA TYPHI, WHICH IS SHED IN THE FECES , URINE , VOMITUS AND ORAL SECRETION BY ACUTELY ILL PERSON.

d.) SALMONELLA INVADE NON – PHAGOCYTOLIC INTESTINAL EPITHELIAL CELLS AS WELL AS TISSUE MACROPHAGES.

D.] TEST FOR THE DIAGNOSIS OF TYPHOID: WIDAL TEST.

E.] SYMPTOMS: 

FIRST WEEK: BACTERAEMIA [PRESENCE OF BACTERIA IN BLOOD] WITH FEVER AND CHILL.

SECOND WEEK: ABDOMINAL PAIN , PROSTRATION [PHYSICALLY WEAK] AND WIDESPREAD RETICULOENDOTHILIAL INVLOVEMENT WITH RASH.

THIRD WEEK: HEMORRHAGE , ULCERATION OF PEYER’S PATCHES WITH INTESTINAL BLEEDING AND SHOCK.

F.] TREATMENT: ANTIBIOTIC THERAPY IS EFFECTIVE. ANTIBIOTICS ARE PRESCRIBED LIKE

  • CIPROFLOXACIN,
  • AZITHROMYSIN

OTHER TREATMENT MAY INCLUDE DRINKING FLUIDS AND SURGERY.

QUESTIONS.

QUES:1) WHICH BACTERIA IS INVOLVED IN THE TYPHOID FEVER ?

a.) SALMONELLA TYPHI                                   b.) SALMONELLA PARATYPHI

c.) BOTH (a) AND (b)                                           d.) NONE OF THESE

 

QUES:2) SALMONELLA TYPHI IS WHICH TYPE OF BACTERIA ?

a.) GRAM NEGATIVE BACTERIA                      b.) GRAM POSITIVE BACTERIA

c.) BOTH (a) AND (b)                                             d.) NONE OF THESE

 

QUES:3) WHICH TEST IS DONE FOR THE DIAGNOSIS OF TYPHOID FEVER ?

a.) ELISA TEST                                                         b.) WIDAL TEST

c.) BLOOD TEST                                                      d.) URINE TE

 

QUES:4) SALMONELLA PARATYPHI CAUSES WHICH TYPE OF FEVER ?

a.) PARATYPHOID FEVER                                    b.) TYPHOID FEVER

c.) BOTH (a) AND (b)                                              d.) NONE OF THESE

 

QUES:5) WHAT IS THE STRUCTURE OF TYPHOID CAUSING BACTERIA ?

a.) FLAGELLATED                                                  b.) NON-FLAGELLATED

c.) ROD SHAPED                                                     d.) BOTH (a) AND (c)

 

QUES:6) ALL ARE THE COMPLICATION OF TYPHOID ULCERS EXCEPT ?

a.) PERFORATION                                                   b.) STRICTURE FORMATION

c.) HEMORRAGE                                                     d.) SEPSIS

 

QUES:7) ALL ARE TRUE ABOUT TYPHOID ULCERS EXCEPT ?

a.) MAINLY AFFECTS ILEUM

b.) MULTIPLE ULCERS AND TRANSVERSE

c.) PERFORATION OCCURS AT THIRD WEEK

d.) PERFORATION TREATED BY SURGERY

 

QUES:8) WHAT IS THE INCUBATION PERIOD OF TYPHOID FEVER ?

a.) 3 MINUTES TO 3 HOURS

b.) 3 MONTHS TO 3 YEARS

c.) 3 DAYS TO 3 MONTHS

d.) 3 HOURS TO 3 MONTHS

 

QUES:9) MOST OF THE UNTREATED PATIENTS WITH TYPHOID FEVER WILL DIE ?

a.) TRUE                                                               b.) FALSE

c.) NITHER TRUE NOR FALSE                      d.) STATEMENT IS INCORRECT

 

QUES:10) TYPHOID FEVER IS COMMONLY ACQUIRED BY ?

a.) CONSUMING FOOD OR WATER CONTAMINATED BY FECAL MATERIAL OF INFECTED PERSON

b.) EATING SALMONELLA  CYSTS IN THE MUSCLES OF INFECTED PERSON

c.) DIRECT SEXUAL CONTACT

d.) DRINKING UNPASTEURIZED MILK

 

REFERENCE: a.) ROBBIN’S BASIC PATHOLOGY

b.) TEXTBOOK OF PATHOLOGY BY HARSH MOHAN

 

SOLUTIONS:

Sol.1: (a) salmonella typhi

Sol.2: (a) gram negative bacteria

Sol.3: (b) WIDAL test

Sol.4: (a) paratyphoid fever

Sol.5: (d) flagellated and rod shaped

Sol.6: (b) stricture formation

Sol.7: (b) multiple ulcers and transverse

Sol.8: (c) 3 days to 3 months

Sol.9: (b) false

Sol.10: (a) consuming food or water contaminated by fecal material of infected person

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