DIMETHINDENE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Dimethindene

IUPAC nomenclature

N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine

Classification

  • H1-receptor antihistamine
  • Alkylamine antihistamine

 

Physiochemical Properties

S. NO. PHYSICAL AND CHEMICAL PROPERTIES
1 Molecular weight 292.4 g/mol
2 Physical appearance Solid
3 Melting point 158oC
4 Solubility 239 mg/LL
5 Octanol/water partition coefficient N/A
5 Presence of ring Phenyl, indene
6 Number of chiral centers 1

 

Mechanism of Action

i. Dimethindene binds to histamine H1 receptors and blocks the action of endogenous histamine.

ii. This provides relief from the negative symptoms produced by the histamine.

 

Structure Activity Relationship

Structure activity of alkyl amines antihistamines can be summarized as:

  • E- and Z- isomers in alkenes shows large difference in activity, where, E-isomers are more potent than Z-
  • The two aromatic rings have different binding environments at the receptors.
  • 5-6 angstrom distance is required between aromatic ring and tertiary aliphatic amine for biding at the receptor.
  • S­-enantiomers have greater affinity for H1 histamine receptors [1]

 

Method of synthesis

i  Diethyl benzylmalonate is reacted with 2-(dimethylamino)ethyl chloride in presence of sodium to give diethyl 2-benzyl-2-(2-(dimethylamino) ethyl)malonate

ii. Above formed compound is reacted with polyphosphoric acid to give 2-(2-dimethylaminoethyl)—indanone.

iii. Last compound is reacted with phenyllithium and 2-ethylpyridine to form 2-(2-(dimethylamino)ethyl)-2,3-dihydro-1- (1-(pyridin-2-yl)ethyl)-1H-inden-1-ol.

iv. Above formed compound is converted into dimethindine by reduction [2]

Medicinal Uses

Dimethindene is used for treatment of:

  • Allergies
  • Hay fever
  • Common cold
  • Watery eyes
  • Runny nose
  • Sneezing
  • Urticaria
  • As an adjuvant in ecszema

  

Side Effects

Side effects of Dimethindene are:

  • Seizures
  • Loss of consciousness
  • Hallucinations
  • Drowsiness
  • Dizziness
  • Allergic reactions
  • Confusion
  • Nervousness
  • Increased urination
  • Blurred vision
  • Dry mouth/throat/nose
  • Restlessness

 

 

MCQs

Q.1 IUPAC nomenclature of drug dimethindene is?

a) N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine

b) N,N-Dimethyl-3-phenyl-3-pyridin-2-yl-butan -1-amine

c) N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]propan-1-amine

d) 2-[(4-Bromophenyl)-phenylmethoxy]-N,N-dimethylpropylamine

Q.2 Which amongst the following statements is/are incorrect related to the SAR of alkylamine antihistamine drugs?

I. E- and Z- isomers in alkenes shows large difference in activity, where, E-isomers are less potent than Z-isomers.

II. The two aromatic rings have different binding environments at the receptors.

III. 5-6 angstorm distance is required between aromatic ring and tertiary aliphatic amine for binding at the receptor.

IV. S-enantiomers have lesser affinity for H1 histamine receptors.

a) I, IV

b) II, IV

c) I, II, IV

d) IV

Q.3 Correct sequence for synthesis of drug dimethindene from diethyl benzylmalonate can be?

I. Reaction with phenyllithium and 2-ethylpyridine

II. Reaction with polyphosphoric acid

III. Reaction with 2-(dimethylamino)ethyl chloride

IV. Reduction

a) II – III – I – IV

b) III – II – I – IV

c) I – II – III – IV

d) II – IV – I – III

Q.4 Side effects of drug dimethindene is/are?

a) Dry mouth

b) Seizures

c) Hallucinations

d) All of the above

Q.5 Match the following drugs with their correct melting point-

i. Dimethindene A. 199oC
ii. Clemastine B. 178oC
iii. Piroxicam C. 158oC
iv.Nalorphine D. 208.5 oC

a. i-A, ii-D, iii-C, iv-B

b. i-D, ii-A, iii-B, iv-C

c. i-C, ii-B, iii-A, iv-D

d. i-B, ii-C, iii-A, iv-D

Q.6 An example of drug from class alkylamine antihistamine drugs is?

a) Dimethindene

b) Nalorphine

c) Edrophonium

d) Phentolamine

Q.7 Type of ring present in the structure of Dimethindene is?

a) Purine

b) Indene

c) Oxazophosphorine

d) Furan

 

 

For More Standard and Quality Question Bank you can Join Our Test Series Programme for GPAT, NIPER JEE, Pharmacist Recruitment Exam, Drug Inspector Recruitment Exams, PhD Entrance Exam for Pharmacy

Participate in Online FREE  GPAT  TEST: CLICK HERE

  Participate in Online FREE  Pharmacist  TEST: CLICK HERE 

Participate in Online FREE  Drug Inspector  TEST: CLICK HERE 

 

ANSWERS

1-a

2-a

3-b

4-d

5-c

6-a

7-b

 

REFERENCES

[1] Lemke TL, Williams DA, editors. Foye’s principles of medicinal chemistry. Lippincott Williams & Wilkins; 2012 Jan 24.

[2] US 2 947 756 (Ciba; 2.8.1960; appl. 5.5.1959; prior. 12.8.1958, 3.11.1958, 10.2.1959).

Leave a Reply

Your email address will not be published. Required fields are marked *

3 × 5 =

Designed & Developed by ThemeXpert