Category: Medicinal Chemistry

LANSOPRAZOLE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Lansoprazole IUPAC nomenclature 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole Classification Proton pump inhibitors Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 369.4  g/mol 2 Physical appearance White to brownish-white crystalline powder 3 Melting point 178-182oC 4 Solubility Freely soluble in dimethylformamide; insoluble […]

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DEXLANSOPRAZOLE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Dexlansoprazole IUPAC nomenclature (R)-(+)-2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole Classification Proton pump inhibitors   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 369.4  g/mol 2 Physical appearance White to brownish-white crystalline powder 3 Melting point 140oC 4 Solubility 0.21 mg/ml 5 Octanol/water […]

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RABEPRAZOLE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Rabeprazole IUPAC nomenclature (RS)-2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole. Classification Proton pump inhibitors   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 359.4  g/mol 2 Physical appearance White to yellowish white solid 3 Melting point 99-100oC 4 Solubility Very soluble in water […]

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PANTOPRAZOLE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Pantoprazole   IUPAC nomenclature (RS)-6-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole Classification Proton pump inhibitors   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 383.4 g/mol 2 Physical appearance Off-white solid 3 Melting point 139-140oC 4 Solubility Freely soluble in water 5 Octanol/water […]

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NITROGLYCERINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Nitroglycerine Or Glyceryl trinitrate   IUPAC nomenclature 1,3-dinitrooxypropan-2-yl nitrate; [3-(nitrooxy)-2-[(nitrooxy)methyl]propyl] nitrate; 1,2,3-trinitroxypropane. Classification Organic nitrate antianginal drug   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 227.09 g/mol 2 Physical appearance Colorless solution 3 Melting point 13.5oC […]

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ERYTHRITOL TETRANITRATE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Erythritol tetranitrate   IUPAC nomenclature [(2R,3S)-1,3,4-trinitrooxybutan-2-yl]nitrate Classification Organic nitrate antianginal drug   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 302.11 g/mol 2 Physical appearance Solid 3 Melting point 61oC 4 Solubility 1.95e-01 gm/L 5 Octanol/water partition […]

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PENTAERYTHRITOL TETRANITRATE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Pentaerythritol tetranitrate   IUPAC nomenclature 2,2-Bis[(nitrooxy)methyl]propane-1,3-diyl dinitrate   Classification Organic nitrate antianginal drug   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 316.14 g/mol 2 Physical appearance White crystals 3 Melting point 140.5oC 4 Solubility Very soluble […]

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ISOSORBIDE DINITRATE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Isosorbide dinitrate   IUPAC nomenclature 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol. Classification Organic nitrate antianginal drug   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 236.14 g/mol 2 Physical appearance Ivory white crystalline powder 3 Melting point 70oC 4 Solubility Freely soluble […]

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