Phenindamine           

IUPAC nomenclature

2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine

Classification

• H1-receptor antihistamine
• Alkylamine antihistamine

Physiochemical Properties

Mechanism of Action

1. Phenindamine competes with histamine for binding with H1 receptor site on the effector cell.
2. Thus, all those pharmacological responses which were mediated by histamine at H1-receptor site are reduced and the intensity of allergic reactions and tissue injury response involving histamine release are reduced.

Structure Activity Relationship

Structure activity of alkyl amines antihistamines can be summarized as:

• E- and Z- isomers in alkenes shows large difference in activity, where, E-isomers are more potent than Z-isomers.
• The two aromatic rings have different binding environments at the receptors.
• 5-6 angstrom distance is required between aromatic ring and tertiary aliphatic amine for biding at the receptor.
• S­-enantiomers have greater affinity for H1 histamine receptors [1]

Method of synthesis

1. Acetophenone, methylamine and formaldehyde are reacted together to get ß,ß’-(methylamino)bis-(propiophenone).
2. The above formed compound is treated with sodium hydroxide to get 3-benzoyl-4-hydroxy-1-methyl-4-phenyl-piperidine.
3. On reaction of last with concentrated hydrogen bromide, 2-methyl-9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine is formed.
4. The last is reduced to get phenindamine. [2]

Medicinal Uses

Phenindamine is used for treatment of:

• Allergies
• Hay fever
• Common cold
• Watery eyes
• Runny nose
• Sneezing

Side Effects

Side effects of Phenindamine are:

• Fatigue
• Dizziness
• Drowsiness
• Sleepiness
• Dry mouth
• Enlarged prostate
• Difficulty in urination
• Headache
• Difficulty breathing
• Closing of throat
• Swellings in face

MCQs

Q.1 Match the following with correct SAR of the alkylamines antihistamine drugs:

1. i-A, ii-C
2. i-A, ii-D
3. i-B, ii-C
4. i-B, ii-D

Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?

• Phenindamine: 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine
•  Diphenhydramine: 2-(diphenylmethoxy)-N,N-dimethylethanamine
•  Auranofin: gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium
•  Meloxicam: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide

a) TFFT

b) FFTF

c) TTTT

d) FFFT

Q.3 Molecular weight of Phenindamine is?

a) 200.5 gm/mol

b) 540.6 gm/mol

c) 261.4 gm/mol

d) 1042 gm/mol

Q.4 Phenindamine binds with which receptor to produce antihistaminic actions?

a) α-receptors

b) ß-receptors

c) Nicotinic receptor

d) H1-receptor

Q.5 Which amongst the following is not a therapeutic use of drug phenindamine?

a) Runny nose

b) Sneezing

c) Hay fever

d) Hypertension

Q.6 Which of the following drug and their classification are correct?

I. Phenindamine: H1 receptor antihistamine drug

II. Cimetidine: H2 receptor antihistamine drug

III. Lansoprazole: Proton pump inhibitor

IV. Thiotepa: Antineoplastic drug

a) I, III

b) I, II, III, IV

c) III, IV

d) I, II, IV

Q.7 Number of chiral centers present in the structure of phenindamine is?

a) 0

b) 1

c) 2

d) 3

For More Standard and Quality Question Bank you can Join Our Test Series Programme for GPAT, NIPER JEE, Pharmacist Recruitment Exam, Drug Inspector Recruitment Exams, PhD Entrance Exam for Pharmacy

Participate in Online FREE  GPAT  TEST: CLICK HERE

  Participate in Online FREE  Pharmacist  TEST: CLICK HERE 

Participate in Online FREE  Drug Inspector  TEST: CLICK HERE 

Participate in CSIR NET JRF Mock Test

Participate GATE Mock Test

ANSWERS

1-a

2-c

3-c

4-d

5-d

6-b

7-b

REFERENCES