Systems of solids in liquids include the most frequently encountered and probably the most important type of pharmaceutical solutions. Many important drugs belong to the class of weak acids and bases. They react with strong acids and bases and, within […]
Effect of Ionic Dissociation and Molecular Association on Partition: The solute can exist partly or wholly as associated molecules in one of the phases or it may dissociate into ions in either of the liquid phases. The distribution law applies […]
Solubility of Liquid in Liquid: Frequently two or more liquids are mixed together in the preparation of pharmaceutical products (e.g. aromatic waters, spirits, elixirs, lotions, sprays, and medicated oils). Liquid–liquid systems can be divided into two categories according to the […]
Solubility of solids in liquids: Factors influencing solubility- Particle size (surface area) of drug particles ↓Particle size → ↑ surface area→ ↑Solubility. Log S/So = 2ϒv/2.303RTr So is the solubility of large particles S is the solubility of fine particles […]
SOLVATION: The interaction between solute and solvent molecule which leads to stabilisation of solute species in the solution is called as solvation. The strength and nature of interaction between the solute molecule and solvent influences many properties of solute like […]