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NICARDIPINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Nicardipine   IUPAC nomenclature 2-[benzyl(methyl)amino]ethylmethyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. Classification Dihydropyridines Calcium channel blockers   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 479.5  g/mol 2 Physical appearance Solid 3 Melting point 136-138oC 4 Solubility 2.2 mg/L 5 Octanol/water partition coefficient […]

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BENDROFLUMETHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Bendroflumethiazide   IUPAC nomenclature 3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 421.4  g/mol 2 Physical appearance White to cream-colored crystalline powder. 3 Melting point 222-223oC 4 Solubility Freely soluble in […]

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BENZTHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Benzthiazide IUPAC nomenclature 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 431.9  g/mol 2 Physical appearance White crystalline powder 3 Melting point 231.5oC 4 Solubility Freely soluble in dimethylformamide; practivally insoluble […]

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CHLOROTHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Chlorothiazide   IUPAC nomenclature 6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide Classification Thiazide diuretic Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 295.7  g/mol 2 Physical appearance White crystalline powder 3 Melting point 342.5oC 4 Solubility Freely soluble in dimethylformamide; practivally insoluble in […]

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HYDROFLUMETHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Hydroflumethiazide   IUPAC nomenclature 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide   Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 331.3 g/mol 2 Physical appearance White to cream colored crystalline powder 3 Melting point 272-273oC 4 Solubility Freely soluble […]

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HYDROCHLOROTHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Hydrochlorothiazide   IUPAC nomenclature 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide   Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 297.7 g/mol 2 Physical appearance White crystalline powder 3 Melting point 274oC 4 Solubility Freely soluble in DMF, NaOH […]

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METHYCLOTHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Methyclothiazide   IUPAC nomenclature 6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide   Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 360.2 g/mol 2 Physical appearance White crystalline powder 3 Melting point 225oC 4 Solubility Slightly soluble in alcohol; […]

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POLYTHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Polythiazide   IUPAC nomenclature 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 439.9 g/mol 2 Physical appearance White crystalline powder 3 Melting point 214oC 4 Solubility Soluble in methanol, acetone and […]

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