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ISOSORBIDE DINITRATE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Isosorbide dinitrate   IUPAC nomenclature 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol. Classification Organic nitrate antianginal drug   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 236.14 g/mol 2 Physical appearance Ivory white crystalline powder 3 Melting point 70oC 4 Solubility Freely soluble […]

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PROPATYL NITRATE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

  Propatyl Nitrate IUPAC nomenclature 2,2-bis(nitrooxymethyl)butyl nitrate Classification Organic nitrate antianginal drug   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 269.17 g/mol 2 Physical appearance Solid 3 Melting point 51.5oC 4 Solubility N/A 5 Octanol/water partition […]

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NICARDIPINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Nicardipine   IUPAC nomenclature 2-[benzyl(methyl)amino]ethylmethyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. Classification Dihydropyridines Calcium channel blockers   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 479.5  g/mol 2 Physical appearance Solid 3 Melting point 136-138oC 4 Solubility 2.2 mg/L 5 Octanol/water partition coefficient […]

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BENDROFLUMETHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Bendroflumethiazide   IUPAC nomenclature 3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 421.4  g/mol 2 Physical appearance White to cream-colored crystalline powder. 3 Melting point 222-223oC 4 Solubility Freely soluble in […]

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BENZTHIAZIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Benzthiazide IUPAC nomenclature 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide Classification Thiazide diuretic   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 431.9  g/mol 2 Physical appearance White crystalline powder 3 Melting point 231.5oC 4 Solubility Freely soluble in dimethylformamide; practivally insoluble […]

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