Category: GPAT Preparation

MITOMYCIN C Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Mitomycin C IUPAC nomenclature {11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate. Classification Mitomycin C falls under the category of antibiotic Antineoplastic cytotoxic drug. [1] Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 334.33 g/mol 2 Appearance Blue-violet crystal form 3 Melting point […]

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ETOPOSIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Etoposide IUPAC nomenclature 4′-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside], 4′ -(dihydrogen phosphate). Classification Etoposide falls under the category of epipodophyllo toxin cytotoxic drug.   Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 588.6 g/mol 2 Appearance Present in solid form; crystal […]

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GPAT 2020 Exam Paper Solved and Answer Key

Dear GPAT 2020 Aspirants Download GPAT 2020 Question Paper GPAT 2020 exam was conducted by National Testing Agency (NTA) on 28 Jan 2020. The exam was mix of various subject questions, with some surprising questions. GPAT 2020 Merit List: Click […]

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IRINOTECAN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Irinotecan IUPAC nomenclature (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’bipiperidine]-1’-carboxylate. Classification Irinotecan falls under the category of camptothecin cytotoxic drug. [1] Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 586.7g/mol 2 Appearance Pale yellow powder 3 Melting point Range between 222-223°C 4 Solubility […]

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TOPOTECAN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Topotecan IUPAC nomenclature (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride. Classification Toptecan falls under the category of camptothecin cytotoxic drug. [1] Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 421.4 g/mol 2 Appearance Present in solid form 3 Melting point Range between […]

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Vincristine (Oncovin) Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Vincristine (Oncovin)  IUPAC nomenclature (3aR,3a1R,4R,5S,5aR,10bR)-Methyl 4-acetoxy-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate.   Classification Vincristine falls under the category of Vinca alkaloids cytotoxic drugs. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 825 g/mol 2 Appearance White crystalline solid 3 Melting point 220 […]

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