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VINBLASTINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Vinblastine IUPAC nomenclature Dimethyl (2β,3β,4β,5α,12β,19α)-15-[(5S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol- 9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3,4-dicarboxylate.   Classification Vinblastine falls under the category of Vinca alkaloids cytotoxic drugs. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 811 g/mol 2 Appearance Solvated needles from methanol 3 Melting point […]

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PACLITAXEL Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Paclitaxel  IUPAC nomenclature (2α,4α,5β,7β,10β,13α)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate. Classification Paclitaxel falls under the category of taxanes. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 853.9 g/mol 2 Appearance Fine white powder 3 Melting point 213-216 °C 4 Solubility Insoluble in […]

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DOCETAXEL Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Docetaxel   IUPAC nomenclature 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}. Classification Docetaxel falls under the category of taxanes. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 807.9 g/mol 2 Appearance Present in solid form 3 Melting point 232°C 4 […]

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5-FLOUROURACIL (5-FU) Synthesis, SAR, MCQ,Structure,Therapeutic Uses, Chemical Property

5-Fluorouracil (5-FU)   IUPAC nomenclature 5-Fluoro-1H,3H-pyrimidine-2,4-dione Classification 5-Fluorouracil falls under the category of pyrimidine antagonist antimetabolite. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 130.08 g/mol 2 Appearance White crystalline powder 3 Melting point 283 °C 4 […]

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CYTARABINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses

Cytarabine  IUPAC nomenclature 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5- (hydroxymethyl)oxolan-2-yl] pyrimidin-2-one Classification Cytarabine falls under the category of pyrimidine antagonist antimetabolite. Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 243.22 g/mol 2 Appearance Colorless crystalline powder 3 Melting point 212.5 °C 4 […]

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Vasaca: Biological Source, Medicinal Uses, Chemical Constituents, Adulterants and MCQ

VASACA 1. Biological sources : • Also known as Adhatoda vasica or Malabar nut. • It belongs to the Acanthaceae family. • The biological source of vasaca is dried and fresh leaves of this plant. 2. Morphological features : • […]

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COLCHICUM Biological sources, Morphology, Phytochemicals, Therapeutic uses and MCQ

COLCHICUM 1. Biological sources : • Also known as Autumn Crocus, Cigdem , colquico, meadow saffron. • Colchicum composed of dried ripe seeds. • It belongs to liliaceae family. • The botanical name of colchicum is Colchi–cum autumnale Linn. 2. […]

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Kurchi: Biological Source, Chemical constituents, Uses, Adultrants, Morphology and MCQ

KURCHI 1. Biological sources: • Kurchi belongs to the Apocynaceae family. • Kurchi bark consist of dried stem bark of Halarrhena antidysenterica(H.pubescens). • It also known as Halorrhenna. • The bark of kurchi is collected from the tree by making […]

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